Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 6/20 | 0.62 |
| ▸ | TRPC6 | Q9Y210 | 6/20 | 0.62 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080527 | 0.88 | TRPC3 (0.66) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL10080530 | 0.86 | TRPC3 (0.63) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL10080528 | 0.81 | RAB9A (0.58) | TRPC3TRPC6ALDH1A1MEN1MAPT | |
| SCHEMBL10080532 | 0.79 | TRPC3 (0.54) | TRPC3TRPC6ALDH1A1MEN1KMT2A | |
| SCHEMBL10080531 | 0.79 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1CNR1CNR2 | |
| SCHEMBL790485 | 0.77 | NPC1 (0.55) | TRPC3TRPC6ALDH1A1MEN1MAPT | |
| SCHEMBL807015 | 0.76 | TRPC3 (1.00) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL807016 | 0.75 | TRPC3 (0.58) | TRPC3TRPC6TRPA1CACNA1CSCN5A | |
| SCHEMBL807014 | 0.73 | TRPC3 (0.73) | TRPC3TRPC6ALDH1A1MEN1MAPT | |
| SCHEMBL10080529 | 0.69 | TRPC3 (0.58) | TRPC3TRPC6GRM5ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |