Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338462 | 0.84 | CYP11B2 (0.51) | CYP11B2CYP11B1SMN1; SMN2GLAHPGD | |
| SCHEMBL21044154 | 0.81 | CYP11B2 (0.56) | CYP11B2CYP11B1SMN1; SMN2KMT2AGLA | |
| SCHEMBL28145764 | 0.80 | CYP11B1 (0.55) | CYP11B2CYP11B1SMN1; SMN2KMT2AGLA | |
| SCHEMBL13996075 | 0.79 | MEN1 (0.62) | CYP11B2CYP11B1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31754524 | 0.77 | KDM4E (0.48) | CYP11B2CYP11B1SMN1; SMN2KMT2AGLA | |
| SCHEMBL317148 | 0.76 | KMT2A (0.60) | SMN1; SMN2KMT2AGLAMEN1POLB | |
| SCHEMBL3761705 | 0.74 | CYP11B1 (0.46) | CYP11B2CYP11B1IRAK4 | |
| SCHEMBL21044544 | 0.74 | CYP11B2 (0.52) | CYP11B2CYP11B1KMT2AMEN1KDM4E | |
| SCHEMBL3293682 | 0.73 | CYP11B1 (0.44) | CYP11B2CYP11B1IRAK4 | |
| SCHEMBL27901846 | 0.73 | KDM4E (0.58) | SMN1; SMN2KMT2AGLAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938296-A | Pyrazine derivatives and pharmaceutical use thereof as adenosine antagonists | ASTELLAS PHARMA INC (JP) | 2007-03-28 | — | — | CN | disclosed |
| EP-1023278-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZINE COMPOUNDS | Abbott Laboratories (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019314-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZINE COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-04-22 | — | — | WO | disclosed |