Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393264 | 0.81 | NPSR1 (0.39) | HTTMC4RNPSR1CSNK2A2CSNK2B | |
| SCHEMBL25043342 | 0.73 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTRECQLHTT | |
| SCHEMBL8398744 | 0.71 | KDM4E (0.37) | HRH4KDM4EALDH1A1MC4RNPSR1 | |
| SCHEMBL15827533 | 0.70 | MC4R (0.31) | ALDH1A1MC4RNPSR1CSNK2A2CSNK2B | |
| SCHEMBL26455581 | 0.69 | HTT (0.41) | HRH4KDM4EALDH1A1MAPTRECQL | |
| SCHEMBL792900 | 0.69 | CARM1 (0.39) | KDM4EMC4RNPSR1CSNK2A2CSNK2B | |
| SCHEMBL736240 | 0.69 | HTT (0.41) | HRH4KDM4EALDH1A1MAPTRECQL | |
| SCHEMBL2296486 | 0.68 | — | — | |
| SCHEMBL8059112 | 0.67 | SIGMAR1 (0.50) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL22066263 | 0.67 | LMNA (0.38) | MC4RNPSR1CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132500-A1 | Antibiotic compounds | MERCK SHARP & DOHME CORP. | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132500-A1 | Antibiotic compounds | NRDC, MRPL21, PEPD | HRH4 2806/4885HRH3 3790/4885KDM4E 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.