Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188689 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL9188865 | 0.79 | PTGS2 (0.61) | ALDH1A1SMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL3971667 | 0.78 | PTGS2 (0.77) | ALDH1A1MAPTPOLBKMT2APTGS2 | |
| SCHEMBL8070861 | 0.78 | SRD5A2 (0.74) | SRD5A2ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL22307858 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL8082813 | 0.77 | SRD5A2 (0.68) | SRD5A2ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL8070499 | 0.77 | SRD5A2 (0.68) | SRD5A2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL3864570 | 0.77 | PTGS2 (0.59) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL6602827 | 0.76 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL22307359 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |