Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 6/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103841 | 0.94 | MEN1 (0.40) | STIM1ORAI1ORAI2IL2SCN9A | |
| SCHEMBL8062134 | 0.91 | STIM1 (0.44) | STIM1ORAI1ORAI2IL2SCN9A | |
| SCHEMBL11940274 | 0.87 | IL2 (0.41) | STIM1ORAI1ORAI2IL2SCN9A | |
| SCHEMBL3096594 | 0.84 | STIM1 (0.44) | STIM1ORAI1ORAI2IL2RORC | |
| SCHEMBL647154 | 0.83 | RAB9A (0.43) | IL2RORCMEN1KMT2A | |
| SCHEMBL3097975 | 0.83 | IL2 (0.39) | STIM1ORAI1ORAI2IL2RORC | |
| SCHEMBL646344 | 0.82 | RXRA (0.44) | STIM1ORAI1IL2RORCRXRA | |
| SCHEMBL647102 | 0.82 | IL2 (0.41) | IL2RORCRXRAMEN1KMT2A | |
| SCHEMBL14373602 | 0.82 | MEN1 (0.39) | STIM1ORAI1ORAI2IL2RORC | |
| SCHEMBL13099813 | 0.81 | RORC (0.37) | STIM1ORAI1ORAI2IL2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038775-A1 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-03-26 | — | — | WO | disclosed |