Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937344 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDCYP3A4TDP1KDM4E | |
| SCHEMBL30937219 | 0.72 | — | — | |
| SCHEMBL9219622 | 0.70 | HTR2C (0.54) | CA12CA9ALDH1A1HPGDCYP3A4 | |
| SCHEMBL30937281 | 0.70 | LTA4H (0.34) | — | |
| SCHEMBL30937335 | 0.70 | ALDH1A1 (0.43) | ALDH1A1MAPTRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL30937330 | 0.70 | — | — | |
| SCHEMBL481982 | 0.69 | ALDH1A1 (0.50) | CA12CA9ALDH1A1HPGDCYP3A4 | |
| SCHEMBL1492628 | 0.67 | AHR (0.32) | ALDH1A1AHR | |
| SCHEMBL10071255 | 0.63 | PDE4D (0.53) | CA12CA9ALDH1A1HPGDHIF1A | |
| SCHEMBL10838940 | 0.63 | CES1 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |