SCHEMBL807149

SCHEMBL807149

c1ccc(CN2CCOc3ccc(-c4nnn[nH]4)cc3C2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER2 P43116 7/20 0.48
CYP2D6 P10635 2/20 0.45
PTK2 Q05397 1/20 0.41
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
ALDH1A1 P00352 2/20 0.39
TSHR P16473 1/20 0.39
CYP3A4 P08684 1/20 0.39
HIF1A Q16665 1/20 0.39
PKM P14618 1/20 0.38
DRD4 P21917 2/20 0.38
HTR2B P41595 2/20 0.38
TMEM97 Q5BJF2 2/20 0.38
SIGMAR1 Q99720 2/20 0.38
CHRM2 P08172 1/20 0.38
HTR1A P08908 1/20 0.38
CHRM3 P20309 1/20 0.38
ADRA1D P25100 1/20 0.38
HTR2C P28335 1/20 0.38
ADRA1A P35348 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807150 0.80 PTGER2 (0.59) PTGER2CYP2D6
SCHEMBL807306 0.78 CYP2D6 (0.53) PTGER2CYP2D6PTK2ALDH1A1TSHR
SCHEMBL3276408 0.75 CYP2D6 (0.51) PTGER2CYP2D6ALDH1A1CYP3A4HIF1A
SCHEMBL3490985 0.74 DYRK1A (0.50) GSK3BNPC1RAB9A
SCHEMBL6436620 0.74 CYP2D6 (0.51) CYP2D6DRD4HTR2BTMEM97SIGMAR1
SCHEMBL4788136 0.72 DRD2 (0.51) PTGER2CYP2D6ALDH1A1CYP3A4HIF1A
SCHEMBL807310 0.72 CYP2D6 (0.48) PTGER2CYP2D6ALDH1A1CYP3A4HIF1A
SCHEMBL807032 0.72 CYP2D6 (0.53) PTGER2CYP2D6CYP3A4HIF1ADRD4
SCHEMBL14023200 0.72 ALDH1A1 (0.53) PTGER2CYP2D6ALDH1A1CYP3A4HIF1A
SCHEMBL15358763 0.72 CYP2D6 (0.60) PTGER2CYP2D6CYP3A4HIF1ADRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037105-A1 METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-03-22 WO disclosed
WO-2012019071-A1 METHODS OF PREVENTING AND TREATING SARCOPENIA THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2012019076-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2008144483-A2 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2008-11-27 WO disclosed