SCHEMBL807306

SCHEMBL807306

c1ccc(CN2CCOc3ccc(-c4ccc5c(c4)OCO5)cc3C2)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.53
PTGER2 P43116 1/20 0.50
SIGMAR1 Q99720 2/20 0.47
TSHR P16473 2/20 0.47
PTK2 Q05397 1/20 0.47
ALDH1A1 P00352 5/20 0.45
PKM P14618 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
LMNA P02545 2/20 0.44
SLC6A12 P48065 1/20 0.43
SLC6A13 Q9NSD5 1/20 0.43
EDNRB P24530 1/20 0.43
EDNRA P25101 1/20 0.43
HTR1A P08908 1/20 0.43
DRD2 P14416 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807150 0.84 PTGER2 (0.59) CYP2D6PTGER2
SCHEMBL3276408 0.80 CYP2D6 (0.51) CYP2D6PTGER2SIGMAR1ALDH1A1PKM
SCHEMBL15358763 0.79 CYP2D6 (0.60) CYP2D6PTGER2SIGMAR1HTR1A
SCHEMBL6436620 0.79 CYP2D6 (0.51) CYP2D6SIGMAR1HTR1A
SCHEMBL807149 0.78 PTGER2 (0.48) CYP2D6PTGER2SIGMAR1TSHRPTK2
SCHEMBL14023200 0.77 ALDH1A1 (0.53) CYP2D6PTGER2ALDH1A1PKMNPSR1
SCHEMBL4788136 0.77 DRD2 (0.51) CYP2D6PTGER2SIGMAR1ALDH1A1PKM
SCHEMBL807310 0.77 CYP2D6 (0.48) CYP2D6PTGER2SIGMAR1ALDH1A1PKM
SCHEMBL807032 0.77 CYP2D6 (0.53) CYP2D6PTGER2SIGMAR1HTR1ADRD2
SCHEMBL807305 0.76 SIGMAR1 (0.71) CYP2D6PTGER2SIGMAR1ALDH1A1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037105-A1 METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-03-22 WO disclosed
WO-2012019076-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2012019071-A1 METHODS OF PREVENTING AND TREATING SARCOPENIA THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2008144483-A2 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2008-11-27 WO disclosed