Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071651 | 0.93 | ADRA1A (0.57) | ADRA1AADRA1BKDM4EALDH1A1HPGD | |
| SCHEMBL8071911 | 0.88 | ADRA1A (0.62) | ADRA1AADRA1B | |
| SCHEMBL8071831 | 0.85 | KDM4E (0.55) | ADRA1AADRA1BKDM4EALDH1A1HPGD | |
| SCHEMBL8077026 | 0.82 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL8077031 | 0.82 | KDM4E (0.55) | ADRA1AADRA1BKDM4EALDH1A1HPGD | |
| SCHEMBL8071975 | 0.82 | ADRA1A (0.56) | ADRA1AADRA1B | |
| SCHEMBL8076826 | 0.79 | ADRA1A (0.56) | ADRA1AADRA1BADRA1D | |
| SCHEMBL8075296 | 0.78 | EHMT2 (0.55) | ADRA1AADRA1BKDM4EALDH1A1HPGD | |
| SCHEMBL8070244 | 0.77 | EHMT2 (0.52) | ADRA1AADRA1B | |
| SCHEMBL11398578 | 0.77 | KDM4E (0.65) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156758-A | Antibacterial quinazoline compounds | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |