Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071898 | 0.81 | PDE4B (0.56) | PDE4BPDE4D | |
| SCHEMBL3804507 | 0.81 | PDE4B (0.68) | PDE4BPDE4DMAPTALDH1A1HPGD | |
| SCHEMBL8024647 | 0.76 | PDE4B (0.46) | PDE4BPDE4D | |
| SCHEMBL8053232 | 0.75 | PDE4B (0.45) | PDE4BPDE4D | |
| SCHEMBL8071504 | 0.73 | CXCR4 (0.46) | PDE4BMAPTALDH1A1 | |
| SCHEMBL8028328 | 0.71 | PDE4B (0.41) | PDE4BPDE4DMAPT | |
| SCHEMBL107308 | 0.70 | TAAR1 (0.54) | MAPTALDH1A1 | |
| SCHEMBL8070648 | 0.69 | PDE4B (0.42) | PDE4BPDE4DALDH1A1ATM | |
| SCHEMBL8066164 | 0.69 | PDE4B (0.44) | PDE4BPDE4DMAPT | |
| SCHEMBL28885373 | 0.68 | SMN1; SMN2 (0.54) | MAPTALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |