Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20460271 | 0.85 | KDM4E (0.65) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL31618101 | 0.83 | HRH3 (0.68) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL24162993 | 0.82 | KDM4E (0.66) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL8821609 | 0.82 | LMNA (0.62) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL20460351 | 0.80 | ALDH1A1 (0.72) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL20460320 | 0.80 | KDM4E (0.67) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL3161038 | 0.80 | MEN1 (0.82) | KDM4EMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL20460365 | 0.79 | LMNA (0.62) | KDM4ELMNAMAPTHTTALOX15 | |
| SCHEMBL13284339 | 0.78 | MEN1 (0.79) | KDM4EALOX15MEN1KMT2AALDH1A1 | |
| SCHEMBL11928962 | 0.78 | CHRM2 (0.72) | KDM4ELMNAHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |