Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161873 | 0.81 | CCNT1 (0.52) | CCNT1CDK9CDK2CCNA2GSK3B | |
| SCHEMBL8162860 | 0.80 | CCNT1 (0.53) | SIRT2CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL8078243 | 0.79 | CCNT1 (0.38) | SIRT2CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL6951956 | 0.75 | CCNE2 (0.62) | CDK2GSK3BGSK3ACCNE2CDK4 | |
| SCHEMBL8072942 | 0.75 | CCNE2 (0.62) | CDK2GSK3BCCNE2CDK4CCND1 | |
| SCHEMBL30834692 | 0.74 | CCNT1 (0.56) | SIRT2CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL8072995 | 0.74 | CCNE2 (0.55) | CDK2CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL3155154 | 0.74 | CCNT1 (0.58) | CCNT1CDK9CDK2CCNA2CCNE2 | |
| SCHEMBL8161831 | 0.74 | CCNT1 (0.64) | CCNT1CDK9CDK2CCNA2PIM1 | |
| SCHEMBL8162035 | 0.73 | PRKACA (0.59) | CCNT1CDK9CDK2CCNA2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153641-A | Pharmaceutically active compounds | ASTRA AKTIEBOLAG (SE) | 2000-11-28 | — | — | US | disclosed |
| EP-0925296-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998011102-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1998-03-19 | — | — | WO | disclosed |