SCHEMBL8073601

SCHEMBL8073601

CCc1c(C(=O)c2cc(C)cc(C)c2)n(COCc2ccccc2)c(=O)[nH]c1=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
BRD4 O60885 1/20 0.39
BRD2 P25440 1/20 0.39
BRD3 Q15059 1/20 0.39
BRDT Q58F21 1/20 0.39
RAB9A P51151 2/20 0.38
MAPT P10636 1/20 0.38
STAT1 P42224 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
POLB P06746 1/20 0.38
ATM Q13315 1/20 0.38
TK1 P04183 1/20 0.38
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
MAT2A P31153 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HPGD P15428 1/20 0.35
UPP1 Q16831 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7031964 0.87 KMT2A (0.39) ALDH1A1MAPTCYP2C19MAT2AMEN1
SCHEMBL6087483 0.85 MEN1 (0.43) ALDH1A1BRD4CYP2C9CYP2C19MEN1
SCHEMBL8390902 0.84 ALDH1A1 (0.45) ALDH1A1BRD4BRD2BRD3BRDT
SCHEMBL10070151 0.83 ALDH1A1 (0.37) ALDH1A1RAB9AMAPTSTAT1NPSR1
SCHEMBL28081686 0.83 ALDH1A1 (0.50) ALDH1A1MAPTPOLBTK1CYP2C9
SCHEMBL7255132 0.82 MEN1 (0.36) ALDH1A1MEN1KMT2ATDP1
SCHEMBL7259855 0.82 MEN1 (0.36) ALDH1A1CYP2C19MEN1KMT2ATDP1
SCHEMBL7254926 0.82 MEN1 (0.36) ALDH1A1MAPTPOLBMEN1KMT2A
SCHEMBL7260730 0.81 MEN1 (0.36) ALDH1A1MEN1KMT2ATDP1
SCHEMBL8069213 0.81 ALDH1A1 (0.41) ALDH1A1MAPTNPSR1POLBTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136815-A VIRICIDES FOR TREATMENT OF AIDS KOREA RESEARCH INST. OF CHEM. TECH. (KR) 2000-10-24 US disclosed