Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507430 | 0.95 | HTR2C (0.41) | HTR2CS1PR5KIF11SLC6A7GHSR | |
| SCHEMBL9875803 | 0.82 | HTR2C (0.41) | HTR2CCTNNB1WNT3A | |
| SCHEMBL7439313 | 0.76 | MAOB (0.46) | HTR2CS1PR5KDM1ABACE1SLC13A5 | |
| SCHEMBL9530357 | 0.76 | HTR2C (0.47) | HTR2CKDM1AGRIN1GRIN2B | |
| SCHEMBL8540798 | 0.75 | HTR2C (0.44) | HTR2CS1PR5KDM1ASLC13A5MAOB | |
| SCHEMBL8543167 | 0.75 | HTR2C (0.44) | HTR2CS1PR5KIF11KDM1ABACE1 | |
| SCHEMBL7435086 | 0.75 | HTR2C (0.49) | HTR2CS1PR5MAOBGRIN1GRIN2B | |
| SCHEMBL9872886 | 0.74 | HTR2C (0.39) | HTR2CS1PR5GRIN1GRIN2B | |
| SCHEMBL8023606 | 0.73 | HTR2C (0.41) | HTR2CS1PR5KDM1AMAOBGRIN1 | |
| SCHEMBL5120102 | 0.72 | HTR2C (0.57) | HTR2CKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017385-A1 | USE OF 4-SUBSTITUTED TETRAHYDROPYRIDINES FOR MAKING MEDICINES ACTING ON TGF-beta 1 | SANOFI-SYNTHELABO (FR) | 2000-07-12 | — | — | EP | disclosed |
| WO-1998053821-A1 | USE OF 4-SUBSTITUTED TETRAHYDROPYRIDINES FOR MAKING MEDICINES ACTING ON TGF-β1 | SANOFI-SYNTHELABO (FR) | 1998-12-03 | — | — | WO | disclosed |