SCHEMBL8074385

SCHEMBL8074385

COc1ccc2c(C)c(C)oc2c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.63
POLB P06746 2/20 0.63
ESR1 P03372 1/20 0.63
APEX1 P27695 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
ESR2 Q92731 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
ALDH1A1 P00352 7/20 0.61
KDM4E B2RXH2 6/20 0.61
HPGD P15428 3/20 0.61
HSD17B10 Q99714 2/20 0.61
GAA P10253 1/20 0.61
CYP1A2 P05177 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
STAT1 P42224 1/20 0.54
MAOB P27338 6/20 0.51
MAOA P21397 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9160809 0.86 ALDH1A1 (0.65) MAPTPOLBESR1APEX1SMN1; SMN2
SCHEMBL436334 0.85 SMN1; SMN2 (0.63) MAPTPOLBESR1APEX1SMN1; SMN2
SCHEMBL16504027 0.81 KDM4E (0.58) MAPTPOLBALDH1A1KDM4EHPGD
SCHEMBL22733326 0.81 KDM4E (0.77) MAPTPOLBESR1APEX1SMN1; SMN2
SCHEMBL7097279 0.81 KDM4E (0.69) MAPTPOLBSMN1; SMN2ALDH1A1KDM4E
SCHEMBL11499651 0.78 KDM4E (0.54) MAPTPOLBESR1APEX1SMN1; SMN2
SCHEMBL4796676 0.78 ALDH1A1 (0.58) MAPTPOLBESR1APEX1SMN1; SMN2
SCHEMBL22106289 0.77 MAOB (0.59) MAPTPOLBSMN1; SMN2ALDH1A1KDM4E
SCHEMBL4965650 0.76 KDM4E (0.64) MAPTPOLBSMN1; SMN2ALDH1A1KDM4E
SCHEMBL15842470 0.76 KDM4E (1.00) MAPTPOLBTDP1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9617255-B2 Organic electroluminescent element, and illumination device and display device each comprising the element Konica Minolta, Inc. (JP) 2017-04-11 US disclosed
US-8852757-B2 Organic electroluminescence element, lighting device and display device KONICA MINOLTA HOLDINGS, INC. (JP) 2014-10-07 US disclosed
US-20110006670-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT, NEW COMPOUND FOR THE SAME, DISPLAY DEVICE AND LIGHTING DEVICE USING THE SAME KONICA MINOLTA HOLDINGS, INC. (JP) 2011-01-13 US disclosed
US-20110006670-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT, NEW COMPOUND FOR THE SAME, DISPLAY DEVICE AND LIGHTING DEVICE USING THE SAME KONICA MINOLTA HOLDINGS, INC. (JP) 2011-01-13 US disclosed
US-20100045171-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT, LIGHTING DEVICE AND DISPLAY DEVICE KONICA MINOLTA HOLDINGS, INC. (JP) 2010-02-25 US disclosed
US-6063810-A ENANTIOMORPHS SYNTHELABO (FR) 2000-05-16 US disclosed
EP-0888324-A1 2-AMINOETHYL-BENZOFURAN DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1999-01-07 EP disclosed
WO-1997032870-A1 2-AMINOETHYL-BENZOFURAN DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1997-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110006670-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT, NEW COMPOUND FOR THE SAME, DISPLAY DEVICE AND LIGHTING DEVICE USING THE SAME AOC2, AOC3, CDYL MAPT 4583/4885POLB 3643/4885ESR1 67/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.