SCHEMBL8074437

SCHEMBL8074437

CCNc1cc(Oc2cccc(C(F)(F)F)c2)nc(C(=O)O)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.58
KDM4E B2RXH2 3/20 0.48
GAA P10253 4/20 0.47
BRAF P15056 2/20 0.47
KDR P35968 2/20 0.47
MAPK14 Q16539 2/20 0.47
TNNI3K Q59H18 2/20 0.47
RAB9A P51151 1/20 0.45
L3MBTL1 Q9Y468 3/20 0.45
MAPK1 P28482 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
ALDH1A1 P00352 3/20 0.44
POLB P06746 1/20 0.44
NTRK1 P04629 2/20 0.44
NPSR1 Q6W5P4 2/20 0.43
TRPA1 O75762 1/20 0.42
P2RY1 P47900 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
PPARG P37231 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8069621 0.89 MAPT (0.56) MAPTKDM4EGAABRAFKDR
SCHEMBL7113284 0.87 MAPT (0.62) MAPTKDM4EGAABRAFKDR
SCHEMBL7049881 0.84 MAPT (0.63) MAPTKDM4EGAARAB9AL3MBTL1
SCHEMBL7108274 0.82 MAPT (0.61) MAPTKDM4EGAARAB9AL3MBTL1
SCHEMBL7108376 0.80 MAPT (0.58) MAPTKDM4EGAAL3MBTL1ALDH1A1
SCHEMBL7110920 0.80 MAPT (0.58) MAPTKDM4EGAARAB9AL3MBTL1
SCHEMBL7107323 0.80 MAPT (0.58) MAPTKDM4EGAABRAFKDR
SCHEMBL7105791 0.80 MAPT (0.55) MAPTKDM4EGAARAB9AL3MBTL1
SCHEMBL7110619 0.80 MAPT (0.74) MAPTKDM4EGAARAB9AL3MBTL1
SCHEMBL8070239 0.77 MAPT (0.49) MAPTKDM4EGAAL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159901-A 6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-12-12 US disclosed
EP-1020444-A1 6-PHENOXYPICOLINIC ACID, ALKYLIDENEHYDRAZIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-07-19 EP disclosed