Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | OGT | O15294 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28150934 | 0.94 | TSHR (0.41) | TSHRLMNAMMP2MMP3MMP9 | |
| SCHEMBL10615670 | 0.82 | GSK3B (0.42) | TSHRLMNAKDM4EMAPTOGT | |
| SCHEMBL8024284 | 0.78 | MAPT (0.39) | LMNAMETAP1KDM4EMAPTOGT | |
| SCHEMBL13024507 | 0.75 | ADH1B (0.42) | LMNAMMP2MMP3MMP9METAP1 | |
| SCHEMBL4909312 | 0.72 | SMN1; SMN2 (0.55) | LMNAKDM4EMAPTBLMMEN1 | |
| SCHEMBL5824304 | 0.70 | NFKB1 (0.50) | TSHRKDM4ENFKB1NFKB2RELA | |
| SCHEMBL29029409 | 0.70 | TSHR (0.44) | TSHRKDM4ENFKB1NFKB2RELA | |
| SCHEMBL20786806 | 0.69 | PTPN1 (0.46) | TSHRLMNAMEN1KMT2APOLB | |
| SCHEMBL31212613 | 0.68 | GSK3B (0.45) | LMNAKDM4EMAPTOGTUSP2 | |
| SCHEMBL2987621 | 0.67 | CCR6 (0.39) | TSHRLMNAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106345521-A | 5-arylidenebarbituric acid derivative and preparation method thereof by simple catalysis | 马鞍山市泰博化工科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-106345521-A | 5-arylidenebarbituric acid derivative and preparation method thereof by simple catalysis | 马鞍山市泰博化工科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| US-20160235752-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF NEW ORLEANS (US) | 2016-08-18 | — | — | US | disclosed |
| WO-2015048634-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | THE UNIVERSITY OF NEW ORLEANS (US) | 2015-04-02 | — | — | WO | disclosed |
| US-7728222-B2 | A photoelectric conversion device comprising an organic dye-sensitizing semiconductor fine particle thin film is prepared by using a dye having a barbituric acid structure as a partial structure and by adsorbing the dye on a semiconductor thin | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2010-06-01 | — | — | US | disclosed |
| EP-1043318-A1 | SALTS OF 5,5'-ARYLIDENEBISBARBITURIC AND 5,5'-ARYLIDENEBIS(2-THIOBARBITURIC) ACIDS AND 5,5'-ARYLIDENEBIS(2-THIOBARBITURIC) ACIDS HAVING AN ANTIBACTERIAL, ANTI-CHLAMYDIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY | Tets, Viktor Veniaminovich (RU) | 2000-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160235752-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | LIPA, ELANE, CLPP | TSHR 4782/4885LMNA 1053/4885MMP2 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.