Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCND1 | P24385 | 5/20 | 0.57 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | PRKACA | P17612 | 3/20 | 0.57 |
| ▸ | PRKACG | P22612 | 3/20 | 0.57 |
| ▸ | PRKACB | P22694 | 3/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | PRKCA | P17252 | 3/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154461 | 0.86 | GSK3B (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7831969 | 0.85 | PRKACA (0.77) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8467101 | 0.82 | PRKD1 (0.53) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8477367 | 0.80 | PRKD1 (0.53) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8477332 | 0.80 | PRKD1 (0.55) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL30834704 | 0.78 | CCNT1 (0.57) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL9085883 | 0.77 | PRKD1 (0.79) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8522822 | 0.77 | MAOA (0.51) | PRKD1TDP1CDK4CCND1CCNE1 | |
| SCHEMBL14041596 | 0.76 | PRKD1 (0.77) | PRKD1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8161651 | 0.76 | GSK3B (0.80) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153641-A | Pharmaceutically active compounds | ASTRA AKTIEBOLAG (SE) | 2000-11-28 | — | — | US | disclosed |
| EP-0925296-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998011102-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1998-03-19 | — | — | WO | disclosed |