Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067090 | 0.86 | SLC6A4 (0.44) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| SCHEMBL8081670 | 0.86 | KDM4E (0.40) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| SCHEMBL5720159 | 0.83 | MAPT (0.43) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL28058117 | 0.79 | ESR1 (0.61) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| Diphenylmethanol SCHEMBL8075180 | 0.78 | HTT (0.51) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| SCHEMBL2191708 | 0.77 | HTT (0.62) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| SCHEMBL8075174 | 0.76 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDLMNASMN1; SMN2 | |
| SCHEMBL4575087 | 0.76 | CTNNB1 (0.47) | ALDH1A1KDM4EHPGDLMNACTNNB1 | |
| SCHEMBL27336022 | 0.74 | ESR1 (0.56) | ALDH1A1KDM4EHPGDLMNAESR1 | |
| SCHEMBL1361465 | 0.74 | CTNNB1 (0.46) | ALDH1A1KDM4EHPGDLMNACTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799198-B1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-0799198-A4 | — | — | 1997-10-15 | — | — | EP | disclosed |
| EP-0799198-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5545669-A | Anti-inflammatory compounds | SMITHKLINE BEECHAM CORPORATION | 1996-08-13 | — | — | US | disclosed |
| WO-1995033461-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |