Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.55 |
| ▸ | RXRB | P28702 | 4/20 | 0.55 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065101 | 0.98 | RXRA (0.55) | RXRARXRBPTGIRKDM4ETDP1 | |
| SCHEMBL9006860 | 0.87 | PTGIR (0.49) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL9006859 | 0.85 | PTGIR (0.48) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL9006866 | 0.85 | PTGIR (0.51) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL8056893 | 0.85 | PTGIR (0.58) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL27320815 | 0.84 | NR4A2 (0.45) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL9006861 | 0.83 | PTGIR (0.50) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL8069442 | 0.83 | PTGIR (0.60) | RXRARXRBPTGIRKDM4ELMNA | |
| SCHEMBL8066060 | 0.81 | PTGIR (0.68) | RXRARXRBPTGIRKDM4ETDP1 | |
| SCHEMBL7964265 | 0.71 | RXRA (0.52) | RXRARXRBPTGIRKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736018-B1 | 4,5-DIARYLOXAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-07-05 | — | — | EP | disclosed |
| US-6025375-A | INHIBITORY ACTIVITY ON PLATELET AGGREGATION, VASODILATING ACTIVITY, ANTIHYPERTENSIVE ACTIVITY OR THE LIKE AND ARE PROSTAGLANDIN I.SUB.2 AGONISTS, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-02-15 | — | — | US | disclosed |
| EP-0736018-A1 | 4,5-DIARYLOXAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017393-A1 | 4,5-DIARYLOXAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-29 | — | — | WO | disclosed |