Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 10/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | USP5 | P45974 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | USP16 | Q9Y5T5 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076051 | 0.83 | CXCL8 (0.40) | LTB4RCXCL8FFAR1FFAR4CHRM1 | |
| SCHEMBL8078846 | 0.81 | CXCL8 (0.39) | LTB4RCXCL8FFAR1FFAR4CHRM1 | |
| SCHEMBL8075660 | 0.80 | LTB4R (0.67) | LTB4RFFAR1FFAR4 | |
| SCHEMBL7021927 | 0.80 | LTB4R (0.66) | LTB4R | |
| SCHEMBL7020175 | 0.78 | LTB4R (0.68) | LTB4RFFAR1FFAR4 | |
| SCHEMBL7022921 | 0.77 | LTB4R (0.55) | LTB4RCXCL8 | |
| SCHEMBL7024326 | 0.76 | LTB4R (0.70) | LTB4RFFAR1 | |
| SCHEMBL7026941 | 0.76 | LTB4R (0.63) | LTB4R | |
| SCHEMBL7030563 | 0.75 | LTB4R (0.54) | LTB4R | |
| SCHEMBL7026815 | 0.74 | LTB4R (0.71) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733044-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1997-03-05 | — | — | EP | claimed |
| EP-0733044-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-25 | — | — | EP | claimed |
| WO-1995015950-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-06-15 | — | — | WO | claimed |
| EP-0812194-B1 | Use of substituted pyridine compounds for treating atopic dermatitis and contact dermatitis | SMITHKLINE BEECHAM CORP (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5990314-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0812194-A4 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORP (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0812194-A1 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0733044-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1997-03-05 | — | — | EP | disclosed |
| EP-0733044-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996026725-A1 | METHOD FOR TREATING ATOPIC DERMATITIS AND CONTACT DERMATITIS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-06 | — | — | WO | disclosed |
| WO-1995015950-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |