Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | FABP6 | P51161 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096590 | 0.83 | KDM4E (0.51) | HPGDKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL2094125 | 0.83 | MEN1 (0.45) | KMT2AALDH1A1MEN1LMNAGAA | |
| SCHEMBL2089715 | 0.83 | KDM4E (0.51) | HPGDKMT2AALDH1A1MEN1GAA | |
| SCHEMBL2093315 | 0.83 | KDM4E (0.51) | HPGDKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL2088493 | 0.80 | EPHX2 (0.50) | ALDH1A1KDM4E | |
| SCHEMBL2094917 | 0.79 | NPC1 (0.50) | HPGDKMT2AMEN1LMNAGAA | |
| SCHEMBL2096333 | 0.76 | KCNN3 (0.44) | — | |
| SCHEMBL11428118 | 0.69 | FABP1 (0.50) | HPGDKMT2AALDH1A1MEN1FABP1 | |
| SCHEMBL3596573 | 0.69 | MMP13 (0.55) | HPGDKMT2AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL206040 | 0.68 | CALM1 (0.42) | ALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494733-A1 | Trifluoromethyl 1-carba(1-dethia)cephems | ELI LILLY AND COMPANY (US) | 1992-07-15 | — | — | EP | claimed |
| US-5099015-A | Antibiotics formed by bromination of trifluoromethanesulfonyl containing cephalosporins | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | claimed |
| EP-0565351-B1 | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | LILLY CO ELI (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0494118-B1 | Process for 3-exomethylenecepham sulfoxide esters | LILLY CO ELI (US) | 1997-04-09 | — | — | EP | disclosed |
| US-5512454-A | Enzymatic acylation of 3-hydroxymethyl cephalosporins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| US-5453502-A | 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof | ELI LILLY AND COMPANY (US) | 1995-09-26 | — | — | US | disclosed |
| EP-0672656-A1 | 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof | ELI LILLY AND COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| EP-0667396-A1 | Enzymatic acylation of 3-hydroxymethyl cephalosporins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5350845-A | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | ELI LILLY AND COMPANY (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0565351-A2 | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | ELI LILLY AND COMPANY (US) | 1993-10-13 | — | — | EP | disclosed |
| US-5221739-A | Acetylation of 3-hydroxymethyl cephalosporins | ELI LILLY AND COMPANY (US) | 1993-06-22 | — | — | US | disclosed |
| EP-0494733-A1 | Trifluoromethyl 1-carba(1-dethia)cephems | ELI LILLY AND COMPANY (US) | 1992-07-15 | — | — | EP | disclosed |
| EP-0494118-A1 | Process for 3-exomethylenecepham sulfoxide esters | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| US-5126446-A | Cyclization of 3-methyl-2-(4-chlorosulfinyl-2-oxo-3-amino-1-azetidinyl)-3-butenoic acid esters using lewis acid friedel-crafts catalyst, nitro compound, anhydrous conditions | ELI LILLY AND COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-5099015-A | Antibiotics formed by bromination of trifluoromethanesulfonyl containing cephalosporins | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |