Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TOP1 | P11387 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11462987 | 0.88 | HTT (0.51) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL8582319 | 0.87 | KDM4E (0.59) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL11491508 | 0.86 | KDM4E (0.49) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL11451643 | 0.84 | HTT (0.50) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL11450871 | 0.84 | KDM4E (0.47) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL9838434 | 0.83 | HTT (0.49) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL6906339 | 0.80 | CA12 (0.55) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL11451163 | 0.79 | ALOX5 (0.46) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL29963170 | 0.78 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1GAABLM | |
| SCHEMBL1666997 | 0.78 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1GAABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373006-A | Combination of derivatives of 1,8-hydroxy and/or acyloxy anthracene or anthrone and of pyrimidine derivatives for inducing and stimulating hair growth and reducing loss thereof | L'OREAL (FR) | 1994-12-13 | — | — | US | claimed |
| EP-0319028-B1 | 1,8-HYDROXY AND/OR ACYLOXY ANTHRACENE OR ANTHRONE AND PYRIMIDINE DERIVATIVES TO INDUCE AND STIMULATE THE HAIR GROWTH AND TO REDUCE HAIR LOSS | L'OREAL (FR) | 1992-08-19 | — | — | EP | claimed |
| EP-0169785-B1 | USE OF 1,8,9-TRIACETOXY-ANTHRACENE AS THE ACTIVE INGREDIENT IN THE PREPARATION OF AN ANTITUMORAL PHARMACEUTICAL COMPOUND | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-10-18 | — | — | EP | claimed |
| EP-0319028-A1 | 1,8-Hydroxy and/or acyloxy anthracene or anthrone and pyrimidine derivatives to induce and stimulate the hair growth and to reduce hair loss | L'OREAL (FR) | 1989-06-07 | — | — | EP | claimed |
| EP-0169785-A1 | Use of 1,8,9-triacetoxy-anthracene as the active ingredient in the preparation of an antitumoral pharmaceutical compound | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1986-01-29 | — | — | EP | claimed |
| US-6127426-A | ANTIALLERGIC AND -INFLAMMATORY AGENTS E.G., TREATING PSORIASIS, BLOCKED ON THE C-10 BY A NONPHENOLIC ARYLACYL OR A PHENYLALKYLIDENE GROUP; LIPOXYGENASE INHIBITORS; ANTIPROLIFERATIVE AGENTS; LOW DOSAGE; SIDE EFFECT REDUCTION | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-10-03 | — | — | US | disclosed |
| EP-0664780-B1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMA (IL) | 1999-12-08 | — | — | EP | disclosed |
| US-5952390-A | ANTIINFLAMMATORY AGENTS; TREATMENT FOR PSORIASIS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1999-09-14 | — | — | US | disclosed |
| US-5844004-A | 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-12-01 | — | — | US | disclosed |
| US-5661187-A | ADMINISTERING TO TREAT AN ALLERGIC OR INFLAMMATORY CONDITION; SIDE EFFECT REDUCTION | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1997-08-26 | — | — | US | disclosed |
| WO-1995028136-A1 | TREATMENT OF WARTS USING ANTHRALINS AND OCCLUSION | TOWSEND, MARVIN, S. (US) | 1995-10-26 | — | — | WO | disclosed |
| EP-0664780-A1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1995-08-02 | — | — | EP | disclosed |
| WO-1995003266-A1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1995-02-02 | — | — | WO | disclosed |
| EP-0319028-B1 | 1,8-HYDROXY AND/OR ACYLOXY ANTHRACENE OR ANTHRONE AND PYRIMIDINE DERIVATIVES TO INDUCE AND STIMULATE THE HAIR GROWTH AND TO REDUCE HAIR LOSS | L'OREAL (FR) | 1992-08-19 | — | — | EP | disclosed |
| EP-0169785-B1 | USE OF 1,8,9-TRIACETOXY-ANTHRACENE AS THE ACTIVE INGREDIENT IN THE PREPARATION OF AN ANTITUMORAL PHARMACEUTICAL COMPOUND | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-10-18 | — | — | EP | disclosed |
| EP-0169785-B1 | USE OF 1,8,9-TRIACETOXY-ANTHRACENE AS THE ACTIVE INGREDIENT IN THE PREPARATION OF AN ANTITUMORAL PHARMACEUTICAL COMPOUND | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-10-18 | — | — | EP | disclosed |
| EP-0319028-A1 | 1,8-Hydroxy and/or acyloxy anthracene or anthrone and pyrimidine derivatives to induce and stimulate the hair growth and to reduce hair loss | L'OREAL (FR) | 1989-06-07 | — | — | EP | disclosed |
| EP-0169785-A1 | Use of 1,8,9-triacetoxy-anthracene as the active ingredient in the preparation of an antitumoral pharmaceutical compound | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1986-01-29 | — | — | EP | disclosed |
| EP-0169785-A1 | Use of 1,8,9-triacetoxy-anthracene as the active ingredient in the preparation of an antitumoral pharmaceutical compound | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1986-01-29 | — | — | EP | disclosed |
| EP-0169785-A1 | Use of 1,8,9-triacetoxy-anthracene as the active ingredient in the preparation of an antitumoral pharmaceutical compound | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1986-01-29 | — | — | EP | disclosed |