SCHEMBL8076410

SCHEMBL8076410

CCOC(=O)CC[SiH](c1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.50
CYP4F2 P78329 3/20 0.49
CYP4A11 Q02928 3/20 0.49
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
TOP2A P11388 2/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 1/20 0.44
ALOX5 P09917 1/20 0.43
TSHR P16473 1/20 0.43
PTPN1 P18031 1/20 0.43
PIN1 Q13526 1/20 0.42
PPID Q08752 1/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8076419 0.82 SMN1; SMN2 (0.47) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
SCHEMBL8084483 0.79 SMN1; SMN2 (0.43) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Succinic Acid Diethyl Ester SCHEMBL28851670 0.77 SMN1; SMN2 (0.58) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Succinic Acid Diethyl Ester SCHEMBL27940678 0.76 SMN1; SMN2 (0.62) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
SCHEMBL28633131 0.74 SMN1; SMN2 (0.51) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
SCHEMBL5837138 0.74 MEN1 (0.46) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Diphenylether SCHEMBL6917810 0.73 SMN1; SMN2 (0.58) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Toluene SCHEMBL8513838 0.73 SMN1; SMN2 (0.54) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Toluene SCHEMBL28096369 0.73 CYP4F2 (0.61) SMN1; SMN2CYP4F2CYP4A11MEN1KMT2A
Ethyl 3-Phenylpropanoate SCHEMBL304816 0.73 TDP1 (0.75) SMN1; SMN2CYP4F2CYP4A11ALDH1A1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP disclosed
EP-0673942-A1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-27 EP disclosed