Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL28234321 | 0.93 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AHPGDCRHBP | |
| SCHEMBL11822828 | 0.89 | MMP1 (0.60) | SMN1; SMN2NPC1RAB9AHPGDCRHBP | |
| Diphenylether SCHEMBL27787224 | 0.89 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AHPGDCRHBP | |
| SCHEMBL646374 | 0.87 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTCYP4F2CYP4A11 | |
| SCHEMBL2773677 | 0.87 | FFAR1 (0.66) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL8955656 | 0.85 | LTA4H (0.60) | SMN1; SMN2NPC1RAB9ALTA4HMAPT | |
| SCHEMBL27472366 | 0.84 | ALOX5 (0.61) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| Succinic Acid Diethyl Ester SCHEMBL27940678 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1CYP4F2CYP4A11LMNA | |
| SCHEMBL6157231 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHPGDCRHBP | |
| SCHEMBL6157238 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHPGDCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044225-A1 | Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives | MILLENNIUM PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2001092249-A2 | CHIRAL AND ACHIRAL SYNTHESIS OF 2-ACYL SUBSTITUTED CHROMANES AND THEIR DERIVATIVES | COR THERAPEUTICS, INC. (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044225-A1 | Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives | ACAT2, ACACA, COASY | SMN1; SMN2 3575/4885NPC1 3933/4885RAB9A 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.