SCHEMBL5837138

SCHEMBL5837138

CCOC(=O)C[SiH](C)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
TSHR P16473 2/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
PPID Q08752 1/20 0.43
ALDH1A1 P00352 3/20 0.42
CYP4F2 P78329 1/20 0.42
CYP4A11 Q02928 1/20 0.42
HTT P42858 1/20 0.41
TRPM8 Q7Z2W7 1/20 0.41
PIN1 Q13526 2/20 0.41
GAA P10253 1/20 0.41
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8076410 0.74 SMN1; SMN2 (0.50) MEN1KMT2ATSHRSMN1; SMN2PPID
SCHEMBL124577 0.70 KMT2A (0.59) MEN1KMT2ASMN1; SMN2PPIDALDH1A1
Succinic Acid Diethyl Ester SCHEMBL28851670 0.70 SMN1; SMN2 (0.58) MEN1KMT2ATSHRSMN1; SMN2ALDH1A1
SCHEMBL19259024 0.70 PIN1 (0.47) MEN1KMT2ATSHRSMN1; SMN2ALDH1A1
SCHEMBL8076419 0.70 SMN1; SMN2 (0.47) MEN1KMT2ATSHRSMN1; SMN2ALDH1A1
Benzene SCHEMBL28160801 0.69 ALDH1A1 (0.68) MEN1KMT2ATSHRSMN1; SMN2PPID
SCHEMBL112999 0.69 ALDH1A1 (0.68) MEN1KMT2ATSHRSMN1; SMN2PPID
Succinic Acid Diethyl Ester SCHEMBL27940678 0.69 SMN1; SMN2 (0.62) MEN1KMT2ATSHRSMN1; SMN2ALDH1A1
SCHEMBL1873977 0.69 ALDH1A1 (0.68) MEN1KMT2ATSHRSMN1; SMN2PPID
SCHEMBL1332625 0.69 ALDH1A1 (0.68) MEN1KMT2ATSHRSMN1; SMN2PPID

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE38947-E1 Method of enantioselectively catalyzing a reaction RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 2006-01-24 US disclosed
EP-0594608-B1 CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESIS RES CORP TECHNOLOGIES INC (US) 1997-10-15 EP disclosed
EP-0594608-A1 CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESIS. RES CORP TECHNOLOGIES INC (US) 1994-05-04 EP disclosed
US-5296595-A Metal complexes with bridging ligands RESEARCH CORPORATION TECHNOLOGIES (US) 1994-03-22 US disclosed
EP-0594608-A4 CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESIS. RES CORP TECHNOLOGIES INC (US) 1993-03-15 EP disclosed
US-5175311-A Reacting olefin with carbene precursor RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1992-12-29 US disclosed
WO-1991014672-A1 CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESIS RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1991-10-03 WO disclosed