SCHEMBL8076470

SCHEMBL8076470

C[Si]1(c2ccccc2)CCC(=O)CC1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
CYP2C9 P11712 1/20 0.38
KMT2A Q03164 1/20 0.38
G6PD P11413 2/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CFTR P13569 1/20 0.32
GOPC Q9HD26 1/20 0.32
CYP2A6 P11509 1/20 0.31
CYP1A2 P05177 1/20 0.31
ALOX5 P09917 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15637037 0.81 TSHR (0.33) G6PDGAAL3MBTL1ALOX12
SCHEMBL8034657 0.77 MEN1 (0.40) MEN1CYP2C9KMT2AGAACFTR
SCHEMBL6440299 0.77 APOBEC3A (0.31) ALOX12
SCHEMBL17885704 0.77 APOBEC3A (0.31) ALOX12
SCHEMBL17885703 0.75 CYP2B6 (0.30)
Ammonia Solution, Strong SCHEMBL27725623 0.73
SCHEMBL1159877 0.71 HTR2C (0.36) MEN1KMT2A
SCHEMBL8021312 0.71 MEN1 (0.32) MEN1CYP2C9KMT2A
SCHEMBL1484049 0.71 TSHR (0.33) G6PDGAAL3MBTL1ALOX12
Hydrochloric Acid SCHEMBL8511729 0.70 HTR2C (0.34) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP claimed
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP disclosed