SCHEMBL6440299

SCHEMBL6440299

C[Si]1(c2ccccc2)CCC1

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
APOBEC3A P31941 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
LMNA P02545 1/20 0.30
TSHR P16473 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17885704 0.95 APOBEC3A (0.31) APOBEC3AAPOBEC3GLMNATSHRALOX12
SCHEMBL17885703 0.92 CYP2B6 (0.30)
Ammonia Solution, Strong SCHEMBL27725623 0.90
SCHEMBL15637037 0.89 TSHR (0.33) LMNATSHRALOX12ACHE
SCHEMBL1159877 0.78 HTR2C (0.36) LMNATSHR
SCHEMBL1484049 0.78 TSHR (0.33) LMNATSHRALOX12ACHE
SCHEMBL17105815 0.77 ACHE (0.40) ACHE
Hydrochloric Acid SCHEMBL8511729 0.77 HTR2C (0.34) LMNA
SCHEMBL8076470 0.77 MEN1 (0.38) ALOX12
SCHEMBL9404264 0.74 LMNA (0.30) LMNATSHRALOX12ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10370588-B2 Organometallic compound and organic light-emitting device including the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2019-08-06 US disclosed
EP-2904034-B1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS MICHELIN & CIE (FR) 2018-04-18 EP disclosed
US-9487629-B2 Method for preparing a statistical copolymer based on diene monomers and cyclic carbosilane monomers COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2016-11-08 US disclosed
US-20160190484-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-06-30 US disclosed
US-20150274896-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS MICHELIN RECHERCHE ET TECHNIQUE, S.A. (CH) 2015-10-01 US disclosed
EP-2904034-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS Compagnie Générale des Etablissements Michelin (FR) 2015-08-12 EP disclosed
WO-2014053509-A1 METHOD FOR PREPARING A STATISTICAL COPOLYMER BASED ON DIENE MONOMERS AND CYCLIC CARBOSILANE MONOMERS COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2014-04-10 WO disclosed
US-6867323-B2 Cross-coupling reaction of organosilicon nucleophiles THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2005-03-15 US disclosed
US-20020183516-A1 Cross-coupling reaction of organosilicon nucleophiles UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN 2002-12-05 US disclosed
WO-2001094355-A1 CROSS-COUPLING REACTION OF ORGANOSILICON NUCLEOPHILES BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2001-12-13 WO disclosed
US-5663397-A MULTISTAGE PROCESS FORMING OXYSILICON RING ENLARGEMENT BY REACTION WITH ACID HALIDE IN THE PRESENCE OF PALLADIUM CATALYST AND ORGANIC BASE DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1997-09-02 US disclosed
US-4132668-A Method of preparing a hydrogen-permeable membrane catalyst on a base of palladium or its alloys for the hydrogenation of unsaturated organic compounds GRYAZNOV VLADIMIR M 1979-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10370588-B2 Organometallic compound and organic light-emitting device including the same L1CAM, AP1M1, L3MBTL1 APOBEC3A 3080/4885APOBEC3G 3062/4885LMNA 1879/4885
US-20020183516-A1 Cross-coupling reaction of organosilicon nucleophiles TST, HPD, PCNA APOBEC3A 2033/4885APOBEC3G 1538/4885LMNA 4232/4885
US-20160190484-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME L1CAM, AP1M1, L3MBTL1 APOBEC3A 3080/4885APOBEC3G 3062/4885LMNA 1879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.