SCHEMBL8034657

SCHEMBL8034657

O=C1CC[Si](c2ccccc2)(c2ccccc2)CC1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CYP2C9 P11712 1/20 0.40
CFTR P13569 1/20 0.34
GOPC Q9HD26 1/20 0.34
CYP1A2 P05177 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
CYP2A6 P11509 1/20 0.33
GAA P10253 2/20 0.31
MAPT P10636 1/20 0.31
RECQL P46063 1/20 0.31
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8040072 0.80 MEN1 (0.33) MEN1KMT2ACYP2C9
SCHEMBL15637376 0.79 MAPT (0.35) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL8076470 0.77 MEN1 (0.38) MEN1KMT2ACYP2C9CFTRGOPC
SCHEMBL7758021 0.76 ACHE (0.31) MEN1KMT2ACYP2C9
SCHEMBL8914562 0.74 MAPT (0.32) MAPT
SCHEMBL3798583 0.74 MAPT (0.32) MAPT
SCHEMBL3898942 0.72 MAPT (0.30) CYP2C9CYP1A2MAPT
SCHEMBL20087445 0.72 MAPT (0.30) CYP2C9CYP1A2MAPT
SCHEMBL5496477 0.72 MAPT (0.30) CYP2C9CYP1A2MAPT
SCHEMBL8021312 0.70 MEN1 (0.32) MEN1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP claimed
JP-8245648-A None JP disclosed
EP-0673942-B1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds SHINETSU CHEMICAL CO (JP) 2000-11-08 EP disclosed
EP-0682031-B1 Silacyclohexane-based carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound SHINETSU CHEMICAL CO (JP) 2000-03-22 EP disclosed
US-5641431-A Silacyclohexanone compound and a method of preparing a silacyclohexane-type liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
JP-H08245648-A PRODUCTION OF SILACYCLOHEXANONE COMPOUND SHIN ETSU CHEM CO LTD 1996-09-24 JP disclosed
US-5527490-A Silacyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-18 US disclosed
US-5523439-A Process for preparing silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-04 US disclosed
EP-0696592-A1 Process for preparing silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-02-14 EP disclosed
EP-0682031-A1 Silacyclohexane carbaldehyde compounds and processes for preparing silycyclohexane-based liquid crystal compounds from the carbaldehyde compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-11-15 EP disclosed
EP-0673942-A1 Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-27 EP disclosed