Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 4/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | HTR5A | P47898 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891132 | 0.83 | CHRM3 (1.00) | CHRM3HTR1AHTR7DRD2HTR1D | |
| SCHEMBL8893676 | 0.79 | HTR1A (0.79) | CHRM3HTR1AHTR7DRD2HTR1D | |
| 8-Oh-Dpat SCHEMBL1682347 | 0.77 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL29565039 | 0.77 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL29389900 | 0.77 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682330 | 0.77 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL496783 | 0.77 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| Hydrochloric Acid SCHEMBL9359964 | 0.76 | CHRM3 (0.42) | CHRM3HTR1AHTR7DRD2HTR1D | |
| 8-Oh-Dpat SCHEMBL1682286 | 0.75 | BLM (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682308 | 0.75 | BLM (1.00) | HTR1AHTR7DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683236-B1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI SYNTHELABO (FR) | 2000-08-09 | — | — | EP | disclosed |
| US-5719308-A | Enzymatic process for the preparation of optically active tetralin derivatives | SANOFI (FR) | 1998-02-17 | — | — | US | disclosed |
| US-5573949-A | Enzymatic process for the preparation of optically active Tetrahydro-2-naphthoic acids | SANOFI (FR) | 1996-11-12 | — | — | US | disclosed |
| EP-0697894-A4 | DOPAMINE D-3 AND SEROTONIN (5-HT 1A?) RECEPTOR LIGANDS AND IMAGING AGENTS | UNIV PENNSYLVANIA (US) | 1996-05-01 | — | — | EP | disclosed |
| EP-0697894-A1 | DOPAMINE D-3 AND SEROTONIN (5-HT 1A?) RECEPTOR LIGANDS AND IMAGING AGENTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0683236-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | SANOFI (FR) | 1995-11-22 | — | — | EP | disclosed |
| EP-0678579-A1 | Enzymatic process for the preparation of optical active tetralin-derivatives | MIDY S.p.A. (IT) | 1995-10-25 | — | — | EP | disclosed |