Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ESRRB | O95718 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22636310 | 0.97 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL25030109 | 0.97 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL4109675 | 0.90 | LMNA (0.54) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL12147930 | 0.88 | EPHX2 (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL6508631 | 0.88 | ALDH1A1 (0.49) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL24757124 | 0.87 | LMNA (0.51) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL25308442 | 0.87 | EPHX2 (0.55) | ALDH1A1LMNAKDM4ESMN1; SMN2LTA4H | |
| SCHEMBL13041145 | 0.85 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL12026347 | 0.84 | AKT1 (0.55) | ALDH1A1LMNAKDM4ESMN1; SMN2CA12 | |
| SCHEMBL26115850 | 0.84 | EPHX2 (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283699-A | Method for synthesizing fluoroalkyl substituted pyrrolidine | 遵义医科大学 | 2023-06-23 | — | — | CN | claimed |
| EP-0641208-B1 | 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 2000-08-02 | — | — | EP | claimed |
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | claimed |
| US-5620986-A | TREATS BENIGN PROSTATIC HYPERTROPHY, SEBORRHEA, FEMALE HIRSUTISM, AND MALE AND FEMALE PATTEN BALDNESS | MERCK & CO., INC. (US) | 1997-04-15 | — | — | US | claimed |
| WO-1993023039-A1 | SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | claimed |
| WO-1993023420-A1 | NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | claimed |
| EP-0060416-B1 | NEW BETA-LACTAM ACETIC ACID DERIVATIVES, THE PROCESS FOR PREPARING THEM, AND THEIR USE AS INTERMEDIATES FOR 1-AZABICYCLO(3.2.0.)HEPT-2-ENE ANTIBIOTICS | GRUPPO LEPETIT S.P.A. (IT) | 1986-08-20 | — | — | EP | claimed |
| EP-0060416-A1 | New beta-lactam acetic acid derivatives, the process for preparing them, and their use as intermediates for 1-azabicyclo(3.2.0.)hept-2-ene antibiotics | GRUPPO LEPETIT S.P.A. (IT) | 1982-09-22 | — | — | EP | claimed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| CN-116283699-A | Method for synthesizing fluoroalkyl substituted pyrrolidine | 遵义医科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-113233972-B | Synthesis method of (R) -2-benzyloxy propionic acid and intermediate thereof | 南京红杉生物科技有限公司 | 2022-09-02 | — | — | CN | disclosed |
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0079134-B1 | STEREOSPECIFIC SYNTHESIS OF 5-PHENYL-2S-PENTANOL | PFIZER INC. (US) | 1985-02-06 | — | — | EP | disclosed |
| US-4427590-A | Triazolobenzodiazepine derivatives | CIBA-GEIGY CORPORATION (US) | 1984-01-24 | — | — | US | disclosed |
| US-4412958-A | Stereospecific synthesis of 5-phenyl-2S-pentanol | PFIZER INC. (US) | 1983-11-01 | — | — | US | disclosed |
| EP-0079134-A1 | Stereospecific synthesis of 5-phenyl-2S-pentanol | PFIZER INC. (US) | 1983-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | ALDH1A1 1451/4885LMNA 387/4885KDM4E 2430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.