Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.54 |
| ▸ | TUBB | P07437 | 3/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082148 | 0.84 | GABRA1 (0.57) | GABRA1GABRB1TUBB4ATUBBTUBA3C | |
| SCHEMBL1493250 | 0.82 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL2417164 | 0.81 | GABRA1 (0.66) | ALDH1A1GABRA1GABRB1GAATUBB4A | |
| SCHEMBL8067518 | 0.80 | GABRA1 (0.59) | CYP1A2CYP3A4TSHRALDH1A1GABRA1 | |
| SCHEMBL9364577 | 0.80 | CYP1A2 (0.96) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL28078271 | 0.80 | GABRA1 (0.78) | CYP1A2CYP3A4TSHRALDH1A1GABRA1 | |
| SCHEMBL4058136 | 0.78 | CYP3A4 (0.57) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL8077077 | 0.78 | GABRA1 (0.60) | CYP3A4ALDH1A1GABRA1GABRB1GAA | |
| SCHEMBL8077306 | 0.78 | GABRA1 (0.65) | ALDH1A1GABRA1GABRB1MAPTMAPK1 | |
| SCHEMBL8075584 | 0.78 | GABRA1 (0.70) | ALDH1A1GABRA1GABRB1GAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520290-A1 | Propofol analogs, process for their preparation, and methods of use | Abraxis BioScience, LLC (US) | 2012-11-07 | — | — | EP | disclosed |
| US-7586008-B2 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7586008-B2 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| WO-2005063665-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC (US) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | CYP3A5, CYP3A4, GABARAP | CYP1A2 35/4885CYP3A4 2/4885CYP2C9 28/4885 |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | CYP3A5, CYP3A4, GABARAP | CYP1A2 35/4885CYP3A4 2/4885CYP2C9 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.