Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807714 | 0.90 | ITK (0.46) | NPC1RAB9ALCKITKTBK1 | |
| SCHEMBL10285559 | 0.89 | KMT2A (0.51) | KMT2ASCDNPC1RAB9ALRRK2 | |
| SCHEMBL807926 | 0.84 | ITK (0.59) | LCKAURKBITKTBK1 | |
| SCHEMBL807541 | 0.80 | ITK (0.55) | LCKAURKBITKTBK1 | |
| SCHEMBL23608014 | 0.78 | BTK (0.42) | ITKTBK1 | |
| SCHEMBL21792649 | 0.78 | BTK (0.42) | ITKTBK1 | |
| SCHEMBL2677855 | 0.77 | NPC1 (0.54) | KMT2ASCDDYRK1ANPC1RAB9A | |
| SCHEMBL2677854 | 0.77 | NPC1 (0.54) | KMT2ASCDDYRK1ANPC1RAB9A | |
| SCHEMBL29261762 | 0.76 | BTK (0.41) | ITKTBK1 | |
| SCHEMBL21792590 | 0.76 | BTK (0.41) | ITKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |