Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.59 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807541 | 0.96 | ITK (0.55) | ITKSSTR5TBK1RORCDHODH | |
| SCHEMBL807803 | 0.91 | ITK (0.58) | ITKSSTR5TBK1RORCDHODH | |
| SCHEMBL807714 | 0.89 | ITK (0.46) | ITKSSTR5TBK1RORCDHODH | |
| SCHEMBL807716 | 0.85 | ITK (0.60) | ITKRORCDHODHBTKHCK | |
| SCHEMBL807822 | 0.85 | ITK (0.81) | ITKSSTR5RORCDHODHBTK | |
| SCHEMBL807721 | 0.84 | KMT2A (0.49) | ITKTBK1LCKAURKB | |
| SCHEMBL808081 | 0.81 | ITK (0.54) | ITKSSTR5TBK1RORCDHODH | |
| SCHEMBL2398982 | 0.81 | ITK (0.57) | ITKSSTR5RORCDHODHBTK | |
| SCHEMBL2398991 | 0.81 | ITK (0.57) | ITKSSTR5RORCDHODHBTK | |
| SCHEMBL793964 | 0.80 | ITK (0.56) | ITKSSTR5RORCDHODHBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |