Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 5/20 | 0.40 |
| ▸ | RORC | P51449 | 4/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807721 | 0.90 | KMT2A (0.49) | ITKRAB9ALCKNPC1TBK1 | |
| SCHEMBL807926 | 0.89 | ITK (0.59) | ITKSSTR5BRD4BTKLCK | |
| SCHEMBL807541 | 0.85 | ITK (0.55) | ITKSSTR5LCKDHODHRORC | |
| SCHEMBL807803 | 0.80 | ITK (0.58) | ITKSSTR5BRD4BTKLCK | |
| SCHEMBL23608014 | 0.80 | BTK (0.42) | ITKBRD4BTKHCKTBK1 | |
| SCHEMBL21792649 | 0.80 | BTK (0.42) | ITKBRD4BTKHCKTBK1 | |
| SCHEMBL798203 | 0.79 | ITK (0.42) | ITKSSTR5RAB9ALCKNPC1 | |
| SCHEMBL21792590 | 0.79 | BTK (0.41) | ITKBTKHCKTBK1 | |
| SCHEMBL29261762 | 0.79 | BTK (0.41) | ITKBTKHCKTBK1 | |
| SCHEMBL10285559 | 0.79 | KMT2A (0.51) | ITKRAB9ABTKLCKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |