Sugi Predict

Sugi Predict / Compounds / SCHEMBL80774

SCHEMBL80774

SCHEMBL80774

CC1(C)c2cc(-c3ccccc3)ccc2-c2nc(-c3cnc4ncc(-c5ccccc5)cc4c3)ccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.37
▸ TDP2 O95551 1/20 0.34
▸ GSK3B P49841 4/20 0.33
▸ GSK3A P49840 3/20 0.33
▸ DYRK1A Q13627 2/20 0.33
▸ CLK4 Q9HAZ1 2/20 0.33
▸ DYRK1B Q9Y463 2/20 0.33
▸ PDGFRB P09619 1/20 0.33
▸ PDGFRA P16234 1/20 0.33
▸ DYRK3 O43781 1/20 0.33
▸ CLK1 P49759 1/20 0.33
▸ CLK2 P49760 1/20 0.33
▸ CLK3 P49761 1/20 0.33
▸ CDK5 Q00535 1/20 0.33
▸ CDK5R1 Q15078 1/20 0.33
▸ DYRK2 Q92630 1/20 0.33
▸ MAP4K4 O95819 2/20 0.33
▸ TYK2 P29597 1/20 0.33
▸ MINK1 Q8N4C8 1/20 0.33
▸ SRPK1 Q96SB4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13045264 0.87 KDM4E (0.41) KDM4ETDP2GSK3BGSK3ADYRK1A
SCHEMBL80785 0.86 PDK2 (0.34) KDM4EPDGFRBPDGFRAPDK2
SCHEMBL81202 0.85 PDK2 (0.38) KDM4ETDP2PDK2
SCHEMBL10037425 0.84 ESR1 (0.40) KDM4ETDP2CLK4MAP4K4TYK2
SCHEMBL82018 0.82 PDK2 (0.37) TDP2PDK2
SCHEMBL80846 0.81 MEN1 (0.33) KDM4EPIK3CDADORA2AADORA1PDK2
SCHEMBL81920 0.81 PDK2 (0.43) PDK2
SCHEMBL81482 0.81 PDK2 (0.43) PDK2
SCHEMBL13045263 0.81 TDP2 (0.39) KDM4ETDP2PDK2
SCHEMBL12127175 0.81 PDK2 (0.40) KDM4ETDP2PIK3CAPDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129899-B1 Azafluorene derivative and organic light-emitting device using the derivative CANON KABUSHIKI KAISHA (JP) 2012-03-06 — — US disclosed
US-8129899-B1 Azafluorene derivative and organic light-emitting device using the derivative CANON KABUSHIKI KAISHA (JP) 2012-03-06 — — US disclosed
US-8110685-B2 Efficient, durable electron transport layers; low driving voltage; simple, low cost production CANON KABUSHIKI KAISHA (JP) 2012-02-07 — — US disclosed
US-8110685-B2 Efficient, durable electron transport layers; low driving voltage; simple, low cost production CANON KABUSHIKI KAISHA (JP) 2012-02-07 — — US disclosed
US-20080154040-A1 AZAFLUORENE DERIVATIVE AND ORGANIC LIGHT-EMITTING DEVICE USING THE DERIVATIVE CANON KABUSHIKI KAISHA (JP) 2008-06-26 — — US disclosed
US-20080154040-A1 AZAFLUORENE DERIVATIVE AND ORGANIC LIGHT-EMITTING DEVICE USING THE DERIVATIVE CANON KABUSHIKI KAISHA (JP) 2008-06-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080154040-A1 AZAFLUORENE DERIVATIVE AND ORGANIC LIGHT-EMITTING DEVICE USING THE DERIVATIVE AZI2, CYP1A2, CYP2C19 KDM4E 852/4885TDP2 919/4885GSK3B 4058/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.