SCHEMBL8077638

SCHEMBL8077638

CCC(=O)O[C@]1(C(=O)COC(C)=O)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.91

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 7/20 0.91
▸ PGR P06401 5/20 0.91
▸ NR1I2 O75469 2/20 0.91
▸ MAPT P10636 2/20 0.91
▸ ADORA3 P0DMS8 2/20 0.91
▸ DRD2 P14416 1/20 0.91
▸ OPRD1 P41143 1/20 0.91
▸ CYP3A4 P08684 7/20 0.81
▸ USP2 O75604 5/20 0.81
▸ LMNA P02545 3/20 0.81
▸ SMN1; SMN2 Q16637 3/20 0.81
▸ CYP2C9 P11712 2/20 0.81
▸ MLNR O43193 1/20 0.81
▸ ABCB11 O95342 1/20 0.81
▸ CYP3A5 P20815 1/20 0.81
▸ PPARG P37231 1/20 0.81
▸ NPSR1 Q6W5P4 1/20 0.81
▸ CYP2D6 P10635 1/20 0.81
▸ HIF1A Q16665 5/20 0.75
▸ CNR1 P21554 2/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30491082 1.00 NR3C1 (0.91) NR3C1PGRNR1I2MAPTADORA3
SCHEMBL25370010 1.00 NR3C1 (0.91) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL13028946 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL11429865 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL4566 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL20097870 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL10013893 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL9768468 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Dexamethasone Dipropionate SCHEMBL43107 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3
Betamethasone Dipropionate SCHEMBL14339597 0.95 NR3C1 (1.00) NR3C1PGRNR1I2MAPTADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12440499-B2 Topical composition MC2 Therapeutics Limited (GB) 2025-10-14 — — US disclosed
US-20230277452-A1 COMPOSITIONS, DEVICES AND METHODS FOR TREATING NASAL, OTIC AND OTHER TISSUE INFECTION AND/OR INFLAMMATION OTICARA, INC. (US) 2023-09-07 — — US disclosed
CN-116600785-A Compositions, devices and methods for treating infection and/or inflammation of the nose, ear and other tissues 奥蒂卡拉股份有限公司 2023-08-15 — — CN disclosed
CN-113499343-B Topical compositions MC2疗法有限公司 2023-07-21 — — CN disclosed
US-20230226077-A1 TOPICAL COMPOSITION MC2 Therapeutics Limited (GB) 2023-07-20 — — US disclosed
US-11696919-B2 Topical composition MC2 Therapeutics Limited (GB) 2023-07-11 — — US disclosed
EP-4203958-A1 COMPOSITIONS DEVICES AND METHODS FOR TREATING NASAL, OTIC AND OTHER TISSUE INFECTION AND/OR INFLAMMATION Oticara, Inc. (US) 2023-07-05 — — EP disclosed
WO-2022047042-A1 COMPOSITIONS DEVICES AND METHODS FOR TREATING NASAL, OTIC AND OTHER TISSUE INFECTION AND/OR INFLAMMATION OTICARA, INC. (US) 2022-03-03 — — WO disclosed
US-9655907-B2 Topical formulations comprising a steroid DR. REDDY'S LABORATORIES LTD. (IN) 2017-05-23 — — US disclosed
US-20160361325-A1 TOPICAL FORMULATIONS COMPRISING A STEROID PRIMUS PHARMACEUTICALS, INC. 2016-12-15 — — US disclosed
US-8858618-B2 Stent TERUMO KABUSHIKI KAISHA (JP) 2014-10-14 — — US disclosed
US-20120197385-A1 STENT TERUMO KABUSHIKI KAISHA (JP) 2012-08-02 — — US disclosed
EP-0721956-B1 21-SUBSTITUTED STEROID COMPOUND NISSIN FOOD PRODUCTS LTD (JP) 2000-08-02 — — EP disclosed
EP-0721956-A1 21-SUBSTITUTED STEROID COMPOUND NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) 1996-07-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160361325-A1 TOPICAL FORMULATIONS COMPRISING A STEROID NR5A1, CYP17A1, TSLP NR3C1 11/4885PGR 233/4885NR1I2 892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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