Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981646 | 0.85 | KMT2A (0.47) | POLBKMT2ACRHBPCRHR2HRH4 | |
| SCHEMBL12110343 | 0.84 | KMT2A (0.51) | KMT2ACRHBPCRHR2ALDH1A1HPGD | |
| SCHEMBL1271706 | 0.83 | ALDH1A1 (0.56) | POLBKMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL1270763 | 0.83 | KMT2A (0.64) | POLBKMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL28205073 | 0.83 | CRHBP (0.65) | POLBKMT2ACRHBPCRHR2HRH4 | |
| SCHEMBL22457644 | 0.81 | CASP1 (0.47) | POLBKMT2AALDH1A1HPGDHRH4 | |
| SCHEMBL5788649 | 0.80 | KMT2A (0.72) | POLBKMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL24766561 | 0.79 | KMT2A (0.49) | POLBKMT2ACRHBPCRHR2ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28615378 | 0.78 | KMT2A (0.70) | POLBKMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL10272785 | 0.77 | KMT2A (0.75) | POLBKMT2AALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013041539-A1 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-28 | — | — | WO | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |