Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077419 | 0.86 | SLC2A1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL8080750 | 0.81 | ALDH1A1 (0.41) | MTNR1AMTNR1BKDM1ANAAAMAOB | |
| SCHEMBL10324528 | 0.81 | NAAA (0.44) | MTNR1AMTNR1BKDM1ANAAAMAOB | |
| SCHEMBL8077823 | 0.81 | TSHR (0.37) | NAAA | |
| SCHEMBL17373052 | 0.77 | SCN4A (0.50) | HTR2AHRH1 | |
| SCHEMBL3509613 | 0.76 | MTNR1A (0.45) | MTNR1AMTNR1BNAAA | |
| Hydrochloric Acid SCHEMBL28350804 | 0.75 | SCN4A (0.48) | HTR2AHRH1 | |
| SCHEMBL10324521 | 0.75 | MEN1 (0.54) | MAOB | |
| SCHEMBL8421133 | 0.72 | MTNR1A (0.72) | MTNR1AMTNR1B | |
| SCHEMBL869237 | 0.72 | SLC2A1 (0.57) | HTR2AHRH1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143790-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | claimed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | claimed |
| US-6143790-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0749418-B1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | disclosed |