Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 8/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10778737 | 0.79 | HSD11B1 (0.61) | CYP17A1CYP19A1HSD11B1P2RX7LMNA | |
| SCHEMBL1770008 | 0.77 | HSD11B1 (0.67) | CYP17A1CYP19A1HSD11B1P2RX7LMNA | |
| SCHEMBL14732863 | 0.77 | TBXAS1 (0.61) | LMNAKMT2ATBXAS1 | |
| SCHEMBL23732837 | 0.77 | TBXAS1 (0.61) | LMNAKMT2ATBXAS1 | |
| SCHEMBL3324032 | 0.77 | HSD11B1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7LMNA | |
| SCHEMBL8067921 | 0.74 | CYP17A1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL8068295 | 0.74 | CYP17A1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL8067920 | 0.74 | CYP17A1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL15947894 | 0.74 | TBXAS1 (0.80) | LMNAALDH1A1KMT2ATBXAS1 | |
| SCHEMBL14732861 | 0.74 | TBXAS1 (0.80) | LMNAALDH1A1KMT2ATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640072-B1 | Derivatives of pyridine as hydroxylase and lyase inhibitors | BTG INT LTD (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5595995-A | ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| EP-0640072-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BTG INTERNATIONAL LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023375-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |