Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073382 | 1.00 | CTSK (0.43) | CTSKCTSSPPARAATMACE | |
| SCHEMBL8073875 | 0.83 | CA1 (0.49) | CTSKCTSSKMT2A | |
| SCHEMBL8065076 | 0.81 | KDM4E (0.38) | CTSKCTSSKMT2A | |
| SCHEMBL5891314 | 0.80 | ATM (0.48) | CTSKCTSSPPARAATMACE | |
| SCHEMBL10062432 | 0.76 | KLK5 (0.57) | CTSKCTSSATMACEKMT2A | |
| SCHEMBL8205328 | 0.76 | KLK5 (0.57) | CTSKCTSSATMACEKMT2A | |
| SCHEMBL12806200 | 0.76 | CTSK (0.52) | CTSKCTSSPPARAATMPPARG | |
| SCHEMBL6685934 | 0.74 | CTSK (0.51) | CTSKCTSSATMMAPTKLK5 | |
| SCHEMBL16181500 | 0.74 | CTSK (0.53) | CTSKCTSSPPARAATMPPARG | |
| SCHEMBL8079961 | 0.73 | PPARA (0.46) | CTSKCTSSPPARAATMACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |