Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 8/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075158 | 0.88 | KDM4E (0.36) | KDM4EALDH1A1HPGDNPSR1CTSS | |
| SCHEMBL5891488 | 0.86 | SCN9A (0.43) | RENSCN9AKMT2A | |
| SCHEMBL8075466 | 0.86 | SCN9A (0.33) | KDM4EALDH1A1HPGDNPSR1REN | |
| SCHEMBL8073460 | 0.82 | CA1 (0.34) | CTSSCTSK | |
| Hydrochloric Acid SCHEMBL8075037 | 0.82 | MEN1 (0.39) | KMT2A | |
| SCHEMBL8078448 | 0.81 | CTSK (0.43) | CTSSCTSKKMT2A | |
| SCHEMBL8073382 | 0.81 | CTSK (0.43) | CTSSCTSKKMT2A | |
| SCHEMBL8079819 | 0.79 | KMT2A (0.39) | RENSCN9AKMT2A | |
| SCHEMBL8075177 | 0.79 | KDM4E (0.34) | KDM4EALDH1A1HPGDNPSR1REN | |
| SCHEMBL9067533 | 0.78 | CTSS (0.35) | RENCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| US-5686472-A | ANTICARCINOGENIC AND -TUMOR AGENTS; SIDE EFFECT REDUCTION; INHIBITION OF FARNESYLATION OF THE RAS PROTEIN | MERCK & CO., INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |