Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078953 | 0.96 | HSD11B1 (0.36) | SLC12A2SLC12A5ALDH1A1LMNATSHR | |
| SCHEMBL8069546 | 0.95 | LMNA (0.37) | SLC12A2SLC12A5ALDH1A1LMNATSHR | |
| SCHEMBL8077242 | 0.95 | LMNA (0.37) | SLC12A2SLC12A5ALDH1A1LMNATSHR | |
| SCHEMBL6140612 | 0.92 | HPGD (0.37) | SLC12A2SLC12A5ALDH1A1LMNATSHR | |
| SCHEMBL8069549 | 0.92 | HTT (0.36) | SLC12A2SLC12A5ALDH1A1LMNAHTT | |
| SCHEMBL8078914 | 0.92 | HTT (0.36) | SLC12A2SLC12A5ALDH1A1LMNAHTT | |
| SCHEMBL6140565 | 0.89 | ALDH1A1 (0.34) | SLC12A2SLC12A5ALDH1A1LMNAGAA | |
| SCHEMBL8663699 | 0.89 | ALDH1A1 (0.34) | SLC12A2SLC12A5ALDH1A1LMNAGAA | |
| SCHEMBL6140313 | 0.89 | SLC12A2 (0.32) | SLC12A2SLC12A5ALDH1A1LMNAPOLB | |
| SCHEMBL8647659 | 0.88 | CXCR4 (0.35) | ALDH1A1LMNATSHRHTTCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6106993-A | HIGHLY SENSITIVE TO ACTINIC RADIATION SUCH AS DEEP-UV, ELECTRON BEAM AND X-RAY, CAN BE DEVELOPED WITH ALKALINE AQUEOUS SOLUTION TO FORM A PATTERN, AND IS THUS SUITABLE FOR USE IN A FINE PATTERNING TECHNIQUE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2000-08-22 | — | — | US | disclosed |