Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17473820 | 0.76 | RIPK1 (0.48) | RIPK1ALOX5ALDH1A1RAB9ANPC1 | |
| SCHEMBL6235762 | 0.73 | RIPK1 (0.46) | RIPK1RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL1027467 | 0.73 | RIPK1 (0.44) | RIPK1ALOX5ALDH1A1RAB9ANPC1 | |
| SCHEMBL14443187 | 0.71 | ALDH1A1 (0.43) | RIPK1ALOX5ALDH1A1RAB9ANPC1 | |
| Bicarbonate SCHEMBL29658892 | 0.71 | ALDH1A1 (0.52) | ALOX5ALDH1A1L3MBTL1TSHRUSP2 | |
| SCHEMBL385865 | 0.70 | ALDH1A1 (0.44) | RIPK1ALOX5ALDH1A1RAB9ANPC1 | |
| Acetic Acid SCHEMBL29696676 | 0.67 | ALDH1A1 (0.53) | ALOX5ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL236223 | 0.67 | ALDH1A1 (0.54) | ALOX5ALDH1A1RAB9AL3MBTL1MAPT | |
| SCHEMBL3174802 | 0.66 | RIPK1 (0.50) | RIPK1ALOX5ALDH1A1RAB9AMAPT | |
| SCHEMBL424806 | 0.66 | HIF1A (0.48) | RIPK1ALDH1A1RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103721-A | TREATMENT OF STROKE ANOXIA; ANTIHYPERGLYCEMIC,-ISCHEMIC AND -EPILEPTIC AGENTS | ZENECA LIMITED (GB) | 2000-08-15 | — | — | US | disclosed |