Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926714 | 0.91 | MAPT (0.35) | ALDH1A1DHFRKDM4EHPGDMAPT | |
| Hydrochloric Acid SCHEMBL4068158 | 0.79 | ALDH1A1 (0.37) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL4094233 | 0.79 | ALDH1A1 (0.37) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL8072623 | 0.78 | ALDH1A1 (0.36) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| SCHEMBL7996886 | 0.78 | ALDH1A1 (0.38) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| SCHEMBL7252933 | 0.78 | ALDH1A1 (0.38) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| SCHEMBL7645589 | 0.76 | ALDH1A1 (0.41) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL2114523 | 0.76 | DHFR (0.36) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL2114856 | 0.76 | DHFR (0.36) | ALDH1A1CYP2A6DHFRKDM4EHPGD | |
| SCHEMBL8679845 | 0.75 | ALDH1A1 (0.36) | ALDH1A1CYP2A6DHFRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025134-A1 | PROCESS FOR THE PREPARATON OF A CATALYST | BOREALIS A/S (DK) | 2000-08-09 | — | — | EP | disclosed |
| EP-0991676-A1 | MULTISTAGE POLYMERIZATION PROCESS USING A CATALYST HAVING DIFFERENT CATALYTICALLY ACTIVE SITES | BOREALIS A/S (DK) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999021895-A1 | PROCESS | BOREALIS A/S (DK) | 1999-05-06 | — | — | WO | disclosed |
| WO-1998057998-A1 | MULTISTAGE POLYMERIZATION PROCESS USING A CATALYST HAVING DIFFERENT CATALYTICALLY ACTIVE SITES | BOREALIS A/S (DK) | 1998-12-23 | — | — | WO | disclosed |