Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663105 | 0.83 | REN (0.49) | PPARGRENMAPTHPGDMAPK1 | |
| SCHEMBL9705878 | 0.74 | KCNA3 (0.50) | HRH3L3MBTL1 | |
| SCHEMBL14168915 | 0.72 | APP (0.44) | HRH3 | |
| SCHEMBL5169443 | 0.70 | NR5A1 (0.58) | HPGD | |
| SCHEMBL22894182 | 0.69 | DRD2 (0.63) | PPARGKCNH2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL15086546 | 0.69 | LMNA (0.53) | SMN1; SMN2MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL21185863 | 0.69 | KCNH2 (0.62) | KCNH2SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL10289213 | 0.69 | REN (0.50) | PPARGSMN1; SMN2ALDH1A1RENMAPT | |
| SCHEMBL15086522 | 0.68 | APP (0.41) | HRH3 | |
| SCHEMBL21379240 | 0.68 | NR5A1 (0.61) | SMN1; SMN2MEN1ALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023964-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-26 | — | — | WO | disclosed |