Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072455 | 0.87 | ALDH1A1 (0.48) | ALOX5STK10SLKL3MBTL1TOP2A | |
| SCHEMBL8086684 | 0.86 | MAPT (0.56) | ALOX5STK10SLKL3MBTL1TOP2A | |
| SCHEMBL8080847 | 0.83 | ALOX5 (0.64) | ALOX5STK10SLKL3MBTL1TOP2A | |
| SCHEMBL8085298 | 0.81 | ALOX5 (0.73) | ALOX5L3MBTL1TOP2AALDH1A1MAPT | |
| SCHEMBL2960392 | 0.81 | TOP2A (0.48) | ALOX5STK10SLKL3MBTL1TOP2A | |
| SCHEMBL2959109 | 0.81 | ALOX5 (0.48) | ALOX5KMT2ACDK2MEN1GAPDH | |
| SCHEMBL8085182 | 0.78 | ALOX5 (0.49) | ALOX5L3MBTL1TOP2AALDH1A1MAPT | |
| SCHEMBL8085334 | 0.78 | ALOX5 (0.66) | ALOX5TOP2AALDH1A1MAPTKDM4E | |
| SCHEMBL8072321 | 0.77 | CDK2 (0.43) | ALOX5STK10SLKTOP2AALDH1A1 | |
| SCHEMBL8080517 | 0.76 | APP (0.41) | ALOX5L3MBTL1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |