Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.66 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAPDH | P04406 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148248 | 0.88 | ALOX5 (0.52) | ALOX5TOP2AKMT2AMEN1PTGS2 | |
| SCHEMBL8085182 | 0.85 | ALOX5 (0.49) | ALOX5TOP2AKMT2AMEN1KDM4E | |
| SCHEMBL2959109 | 0.82 | ALOX5 (0.48) | ALOX5PTPRCKMT2AGAPDHMEN1 | |
| SCHEMBL8085088 | 0.79 | ALOX5 (1.00) | ALOX5TOP2APTPRCKMT2AGAPDH | |
| SCHEMBL8080438 | 0.78 | ALOX5 (0.52) | ALOX5TOP2AKMT2AGAPDHMEN1 | |
| SCHEMBL8081965 | 0.77 | ALOX5 (0.43) | ALOX5PTPRCGAPDHPTGS2PTGS1 | |
| SCHEMBL8086684 | 0.77 | MAPT (0.56) | ALOX5TOP2AKMT2AGAPDHMEN1 | |
| SCHEMBL8072455 | 0.76 | ALDH1A1 (0.48) | ALOX5TOP2AKMT2AMEN1KDM4E | |
| SCHEMBL30637547 | 0.76 | ALOX5 (1.00) | ALOX5TOP2AKMT2AMEN1KDM4E | |
| SCHEMBL29582148 | 0.76 | ALOX5 (1.00) | ALOX5TOP2AKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |