Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.38 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.38 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803709 | 0.93 | PLOD2 (0.42) | WDR5CDK5CDK5R1PLOD2PLOD3 | |
| SCHEMBL6799329 | 0.84 | HRH4 (0.41) | ALDH1A1RAB9AKDM4EMEN1POLB | |
| SCHEMBL6798831 | 0.82 | CDC7 (0.43) | CHEK1ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL6799182 | 0.80 | JUN (0.48) | PLOD2PLOD3PLOD1ALDH1A1 | |
| SCHEMBL6799336 | 0.72 | TSHR (0.41) | CYP1A2CYP2C19ALDH1A1RAB9AKDM4E | |
| SCHEMBL6804364 | 0.70 | PRKDC (0.48) | ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6808781 | 0.68 | MAPK14 (0.47) | CYP1A2CYP2C19KDM4EMAPK14 | |
| SCHEMBL14598726 | 0.66 | POLB (0.44) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL8079069 | 0.65 | HPGD (0.38) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18228362 | 0.63 | CYP3A4 (0.54) | MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048880-A | THERAPY FOR CYTOKINE SENSITIVE DISEASES | PFIZER PHARAMACEUTICALS INC. (JP) | 2000-04-11 | — | — | US | disclosed |