SCHEMBL8080562

SCHEMBL8080562

O=C1NCc2c1cc1ccc3c(c1c2-c1ccc(Br)cc1)OCO3

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.56
CDK2 P24941 2/20 0.34
GRM2 Q14416 1/20 0.32
PIM1 P11309 2/20 0.32
CSNK1A1 P48729 1/20 0.32
CDK5 Q00535 1/20 0.32
ROCK1 Q13464 1/20 0.32
DYRK1A Q13627 1/20 0.32
LRRK2 Q5S007 1/20 0.32
CLK4 Q9HAZ1 1/20 0.32
DYRK1B Q9Y463 1/20 0.32
CSNK2A1 P68400 1/20 0.32
PIM3 Q86V86 1/20 0.32
BRSK1 Q8TDC3 1/20 0.32
MAP3K9 P80192 1/20 0.32
MAP3K11 Q16584 1/20 0.32
PTGS2 P35354 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP1B1 Q16678 1/20 0.31
NQO2 P16083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8084967 0.89 ALOX5 (0.56) ALOX5CDK2PTGS2NQO2HSP90AA1
SCHEMBL8084927 0.89 ALOX5 (0.56) ALOX5CDK2GRM2PTGS2HSP90AA1
SCHEMBL8072504 0.89 ALOX5 (0.56) ALOX5CDK2MAPTKDM4E
SCHEMBL2952410 0.89 ALOX5 (0.71) ALOX5MAPTKDM4E
SCHEMBL8081502 0.89 ALOX5 (0.55) ALOX5CDK2GRM2CLK4DYRK1B
SCHEMBL8072655 0.88 ALOX5 (0.54) ALOX5CDK2PIM1ROCK1MAP3K9
Hydrochloric Acid SCHEMBL8072479 0.87 ALOX5 (0.53) ALOX5CDK2PIM1ROCK1MAP3K9
SCHEMBL8080428 0.86 ALOX5 (0.53) ALOX5CDK2GRM2DYRK1ACLK4
SCHEMBL8085115 0.86 ALOX5 (0.53) ALOX5MAPTNPSR1KDM4E
SCHEMBL8072251 0.86 ALOX5 (0.53) ALOX5CDK2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6030967-A AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-02-29 US disclosed